Initial Therapy of Bacterial Meningitis with Cefuroxime: Experience in 167 Children

Cefuroxime treatment of bacterial meningitis in infants and children.

Recently, ampicillin- and chloramphenicol-resistant strains of Haemophilus influenzae type b and multiply-resistant Salmonella strains have appeared in some areas of the world. Therefore, alternative drug therapy for infections caused by these organisms is being sought. We used cefuroxime to successfully treat five children with H. influenzae type b meningitis and two children with Salmonella m...

Recurrent bacterial meningitis in children: our experience with 14 cases.

Recurrent bacterial meningitis is an uncommon but life-threatening condition. The aim of this study was to evaluate the demographic, clinical, microbiological, and radiological features of recurrent bacterial meningitis in children. Fourteen patients (10 male, 4 female) treated for recurrent bacterial meningitis were reviewed. The mean age of the patients was 87 months (range: 6 months to 13 ye...

Cefuroxime plasma and CSF levels in children with meningitis.

Cefuroxime (25 mg/kg) given intravenously every four hours to 7 children with bacterial meningitis resulted in satisfactory therapeutic blood and CSF levels. All children made a full recovery and side effects were absent.

Bacterial meningitis in children.

Microbiologic causes of meningitis include bacteria, viruses, fungi, and parasites. Before routine use of pneumococcal conjugate vaccine, bacterial meningitis affected almost 6000 people every year in the United States, and about half of all cases occurred in children 18 years old or younger. Prompt and accurate diagnosis and adequate treatment of bacterial meningitis in children remains a majo...

Bacterial meningitis in children